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Cancer Clinical Trials

Akron General's McDowell Cancer Institute provides patients with access to care quickly. We also offer the newest therapies, diagnostics and surgical techniques to help minimize side effects and improve outcomes. A research site with national clinical trials, we offer treatment options that may help extend and improve lives. The McDowell Cancer Institute is a member of six National Cancer Institute cooperative groups including: the American College of Radiology Imaging Network (ACRIN), American College of Surgeons Oncology Group (ACOSOG), Radiation Therapy Oncology Group (RTOG), Southwest Oncology Group (SWOG), National Surgical Adjuvant Breast and Bowel Project (NSABP), and the Gynecologic Oncology Group (GOG). We also participate in pharmaceutical and in-house investigator-initiated studies.

Read more from Akron General:
What is a Clinical Trial?

View all Akron General Clinical Trials

For more information about options available through our cancer center clinical trials, please contact the McDowell Cancer Institute Research Department at 330-344-6348.

See below for active trials at the Akron General McDowell Cancer Institute

Additional resources for cancer clinical trials.

National Institutes of Health, National Cancer Institute
www.nci.nih.gov

American Cancer Society
www.cancer.org

 Date Updated: 23-JAN-2014
  
Brain Cancer
Breast Cancer
Cervical Cancer
Colon Cancer
Esophageal Cancer
Gynecology Cancer
Head and Neck Cancer
Leukemia
Leukemia - Registry Study
Lung Cancer
Lymphoma Cancer
Pain Management
Pancreas Cancer
Prostate Cancer

Cancer Clinical Trials

Bone and Spine Cancer

Title(s):
RTOG 0631. Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Brain Cancer

Title(s):
RTOG 1205. Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Brain Cancer

Title(s):
CTSU A221101. A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) to Reduce Cancer-Related Fatigue in Patients with High Grade Glioma

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
NSABP B-43. A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Investigator(s):
Andrew Fenton, MD

Contact Information:
McDowell Cancer Research 330-344-6348


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Breast Cancer

Title(s):
CTSU SCUSF 0806. Phase II Placebo-Controlled Trial of Lisinopril and Coreg CR to Reduce Cardiotoxicity in Patients with Breast Cancer Receiving (neo) Adjuvant Chemotherapy with Trastuzumab (Herceptin)

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
SWOG 1007. A Phase II Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or less

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
RTOG 1119. Phase II Randomized Study Of Whole Brain Radiotherapy In Combination With Concurrent Lapatinib In Patients With Brain Metastasis From HER2-Positive Breast Cancer- A COLLABORATIVE STUDY OF RTOG AND KROG.

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
SWOG 1207. Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
NSABP B-51/RTOG 1304. A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

Investigator(s):
Andrew Fenton, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
SWOG 1202. A Randomized Placebo-Controlled Phase III Study of Duloxetine for Treatment of Aromatase Inhibitor (Al)-Associated Musculoskeletal Symptoms in Women with Early Stage Breast Cancer

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348.


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Breast Cancer

Title(s):
13049. Neoadjuvant Breast Registry - Symphony ™ Trial (NBRST) (pronounced "in breast")

Investigator(s):
Mary Murray, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
CTSU E1Z11. Treating Aromatase Inhibitor Musculoskeletal Symptoms related to Anastrozole in Female Patients With Stage I-III Breast Cancer --A Cohort Study to Evaluate Genetic Predictors for Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS)

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
CTSU E2112. A Randomized Phase III Trial of Endocrine Therapy plus Entinostat/Placebo in Postmenopausal Patients with Hormone Receptor-Positive Advanced Breast Cancer

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
14017. Use of Intraoperative MRI During Breast Conservation Surgery: A Pilot Study

Investigator(s):
Andrew Fenton, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
NSABP B-52. A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients with Hormone Receptor-Positive, HER2-Positive, Large Operable and Locally Advanced Breast Cancer Treated with Neoadjuvant Therapy of Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation

Investigator(s):
Andrew Fenton, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
NSABP B-55/BIG 6-13. A Randomised, Double-Blind, Parallel Group, Placebo-Controlled Multi-Centre Phase III Study to Assess the Efficacy and Safety of Olaparib Versus Placebo as Adjuvant Treatment in Patients with Germline BRCA1/2 Mutations and High Risk HER2 Negative Primary Breast Cancer Who Have Completed Definitive Local Treatment and Neoadjuvant or Adjuvant Chemotherapy

Investigator(s):
Andrew Fenton, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Breast Cancer

Title(s):
CTSU A011202. A Randomized Phase III Trial Evaluating the Role of Axillary Lymph Node Dissection in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Cervical Cancer

Title(s):
RTOG/GOG 0724. Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Cervical Cancer

Title(s):
RTOG 1203. A Randomized Phase III Study Of Standard VS. IMRT Pelvic Radiation For Post-Operative Treatment Of Endometrial And Cervical Cancer (Time-C)

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research


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Colon Cancer

Title(s):
CTSU CALGB 80702. A Phase III Trial of 6 Versus 12 Treatments of Adjuvant FOLFOX plus Celecoxib or Placebo for Patients with Resected Stage III Colon Cancer.

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Colon Cancer

Title(s):
13026. Ohio Colorectal Cancer Prevention Initiative: Universal Screening for Lynch Syndrome

Investigator(s):
Kevin Lowe, MD

Contact Information:
McDowell Cancer Research at 330-344-6348.


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Esophageal Cancer

Title(s):
SWOG 1201. A Randomized Phase II Pilot Study Prospectively Evaluating Treatment for Patients Based on ERCC1 (Excision Repair Cross-Complementing 1) for Advanced/Metastatic Esophageal, Gastric, or Gastroesophageal Junction (GEJ) Cancer

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Gynecology Cancer

Title(s):
GOG 0260. A Phase II Evaluation Of Elesclomol Sodium And Weekly Paclitaxel In The Treatment Of Recurrent Or Persistent Platimum-Resistant Ovarian, Fallopian Tube Or Primary Peritoneal Cancer

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Head and Neck Cancer

Title(s):
CTSU E1305. A Phase III Randomized Trial of Chemotherapy with or without Bevacizumab in Patients with Recurrent or Metastatic Head and Neck Cancer

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Head and Neck Cancer

Title(s):
RTOG 0920. A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Head and Neck Cancer

Title(s):
RTOG 1216. Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin versus Docetaxel versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Head and Neck Cancer

Title(s):
CTSU E1311. A Randomized, Placebo Controlled Phase II Trial of Afatinib (BIBW2992) as Adjuvant Therapy Following Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma at High Risk of Recurrence

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Head and Neck Cancer

Title(s):
NRG-HN001. Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348.


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Leukemia

Title(s):
CTSU E2906. Phase III Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin & Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly Diagnosed Acute Myeloid Leukemia in Older Adults (Age >= 60 Years)

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Leukemia - Registry Study

Title(s):
11001. CA180-330 (SIMPLICITY) Studying Interventions for Managing Patients with Chronic Myeloid Leukemia in Chronic Phase: The 5-Year Prospective Cohort Study

Investigator(s):
John Petrus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lung Cancer

Title(s):
CTSU CALGB 30610. Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lung Cancer

Title(s):
RTOG 0937. Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer (ED-SCLC)

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lung Cancer

Title(s):
CTSU E5508. Randomized Phase III Study of Maintenance Therapy with Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lung Cancer

Title(s):
RTOG 1306. A Randomized Phase II Study of Individualized Combined Modality Therapy for Stage III Non-Small Cell Lung Cancer (NSCLC)

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lung Cancer

Title(s):
CTSU A151216. Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lung Cancer

Title(s):
CTSU A081105. Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lung Cancer

Title(s):
CTSU E4512. A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Lymphoma Cancer

Title(s):
CTSU E1412. Randomized Phase II Open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Pain Management

Title(s):
13070. RELIEF (Rapid Evaluation of Lifestyle, Independence, and Elimination of Breakthrough Cancer Pain with Freedom from Oral Discomfort Through the Use of Abstral® (fentanyl) Sublingual Tablets)

Investigator(s):
John Petrus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Pancreas Cancer

Title(s):
RTOG 0848. A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Pancreas Cancer

Title(s):
RTOG 1201. A Phase II Randomized Trial of High versus Standard Intensity Local or Systemic Therapy for Unresectable Pancreatic Cancer

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Pancreas Cancer

Title(s):
CTSU E2211. A Randomized Phase II Study of Temozolomide or Temozolomide and Capecitabine in Patients with Advanced Pancreatic Neuroendocrine Tumors

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Prostate Cancer

Title(s):
RTOG 0534. A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA after Radical Prostatectomy

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Prostate Cancer

Title(s):
RTOG 0815. A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy with or without Short-Term Androgen Deprivation Therapy for Patients with Intermediate-Risk Prostate Cancer

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Prostate Cancer

Title(s):
CTSU CALGB 70807. The Men's Easting and Living (MEAL)Study: A Randomized Trial of Diet to Alter Disease Progression in Prostate Cancer Patients on Active Surveillance

Investigator(s):
Esther Rehmus, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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Prostate Cancer

Title(s):
RTOG 0924. Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial

Investigator(s):
Mitchel Fromm, MD

Contact Information:
McDowell Cancer Research at 330-344-6348


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